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Women’s Health

Squaring the Circle of Lifestyle, Dementia, Diabetes and Epigenetics

According to the World Health Organization, 55 million people globally are impacted by dementia,

with an estimated 10 million increase every year [1]. Women are more likely to get dementia, with

women being 2 in 3 of those diagnosed [2]. Diabetes is another chronic illness that affects 1 in 9

women [3]. Epigenetic studies which help explain the role of environment in influencing your genes,

provides evidence of how lifestyle habits play a major role in these diseases. These genetic changes

can be permanent and carried on to the next generation. Dementia and diabetes have a genetic

connection, and environmental factors can affect gene function governing these illnesses. Despite

the severity of these disorders, it is possible to greatly lower the risk by implementing healthier

lifestyle changes.


Diabetes and dementia: what are the risk factors?


Diabetes and dementia, like many other chronic diseases have similar risk factors and are

interlinked. Their connection is well established to the extent that Alzheimer’s (most common type

of dementia) is also called Type 3 diabetes [4]. In fact, being diabetic increases the risk of Alzheimer’s

by over 50% [5].


Apart from family history, some common risk factors like obesity, high blood pressure, high

cholesterol, lack of physical activity, and poor dietary choices can increase the risk of diabetes and

dementia. The good news is that these risk factors can be managed to greatly reduce your chance of

getting these disorders.


Diabetes and dementia: How can you protect yourself?


The Women’s Brain Health Initiative (WBHI) is a foundation formed in the USA and Canada and

focuses on improving women’s cognitive health. They recommend 6 areas that must be focused on

to improve brain health: nutrition, exercise, sleep, stress management, keeping your brain active,

and having a social network. You can easily implement these to reap big benefits and live a healthier

life to reduce your risk of diabetes and dementia:


1. Eat right for a healthier body and brain.


You are what you eat. It might be overwhelming to follow every new diet that promises miracles.

There is one diet that is well evidenced to decrease the risk of diabetes and dementia. The

Mediterranean diet has shown to reduce the risk of diabetes by 19-23% [6] and of Alzheimer’s by

almost 40% [7].


The Mediterranean diet is the diet that is local to areas like Turkey, Greece, Italy, Morocco, Spain

and surrounding areas. This traditional diet emphasizes increased intake of whole grains, beans and

legumes, fruits and vegetables, fish and olive oil. It encourages limiting intake of red meat and

sweets. A more advanced version of this diet is the MIND (Mediterranean-DASH Diet Intervention

for Neurodegenerative Delay) diet if you are looking to maximize your health benefits. Studies show

that long term adherence to the MIND diet will lower the risk of Alzheimer’s by 53% [8]. The

nutrients in this diet also help establish good blood sugar balance. The MIND diet has clear

recommendations on 10 foods that are beneficial and a few foods that are unhealthy and must be

limited. MIND diet recommendations include [8]:


  • Green leafy vegetables: >6 servings a week

  • Nuts: ≥5 servings a week

  • Other vegetables: >1 serving a day


  • Whole grains: ≥3 servings a day

  • Berries: ≥2 servings a week

  • Beans: >3 meals a week

  • Fish (not fried): ≥1 meals a week

  • Poultry like chicken (not fried): ≥2 meals a week

  • Olive oil: Main oil to be used


Foods like butter, margarine, cheese, red meat, fried foods, and sweets should be limited as follows:


  • Butter, Margarine: <1 tablespoon per day

  • Cheese: <1 serving a week

  • Red meat: <4 meals a week

  • Fried foods: <1 time a week

  • Sweets: <5 servings a week


2. Exercise to for a fitter body and brain.


Increasing your physical activity levels is one of the best lifestyle modifications you can make to

improve your health long term. In fact, a major review listed exercise as a treatment therapy for

over 26 diseases, including dementia and diabetes [9]. You don’t have to spend hours in the gym to

get the most out of exercise. Even a simple activity such as walking can provide health benefits.

Starting out with just 3800 steps a day can lower your dementia risk by 25% [10]. In addition, those

who did moderate intensity exercise for 150 minutes/week as part of their lifestyle modifications,

had a 58% lower risk of getting diabetes [11]. A study that spanned over 4 decades looked at the

lives of women between the ages of 38-60 years. Women who topped the fitness charts had an

almost 90% lower risk of getting Alzheimer’s [12]. Exercising helps your body use blood glucose more

effectively and keeping it balanced- an important aspect in diabetes. This was seen in women who

exercised 3 times a week at a moderate-vigorous intensity [13].


3. Sleep well for relaxed body and brain.


Getting a good quality sleep essential for a healthy body. Your brain is working hard while you sleep

to promote good health. In fact, getting less sleep (under 7-8 hours) can increase the risk of diabetes

by 40% [14]. As for brain health, your brain is busy cleaning up waste materials and organizing and

storing memories and important information while you sleep. Getting adequate sleep is protective

towards dementia. A study among older women found that there was a 30% higher risk of dementia

among women who regularly slept for less than 6 hours [15]. The Alzheimer’s Association

recommends some tips to improve sleep quality: establish regular sleep time by sleeping and waking

up at the same time, have a good sleep hygiene routine, and avoid stimulants like caffeine and

screen time before bed [16].


4. Manage your stress for a rejuvenated body and brain.


Constantly being under high levels of stress can be detrimental to your body and brain. Women who

regularly suffered from moderate-to-high levels of stress had a higher risk of getting diabetes after 3

years [17]. Similarly, middle aged women who were under a high level of stress often had around

20% higher risk of developing dementia in their 70s [18]. When your stress hormone is consistently

high, there is increased levels of brain chemicals associated with Alzheimer’s disease [18]. There are

many stress-management techniques that you can incorporate in your daily life to effectively

manage it. Even a simple activity like spending 20-30 minutes in nature, 3 times per week can

decrease your stress hormone by 20%, [20] and thus the risk of dementia and diabetes. Finding

enjoyable activities that help you relax and managing your day correctly can greatly reduce stress

levels.


5. Keep your brain active to stay protected.


Keeping your brain mentally stimulated can help preserve brain function. This is even true among

those who were diabetic. Mentally stimulating activities reduced the risk dementia and of diabetes-

damage in those who developed dementia [21]. Having hobbies like knitting, reading, volunteering,

playing board games etc can greatly lower the risk of dementia. Women their 30 and 40s who

partook in intellectual activities had a 38% lower risk getting dementia in old age [26]. Pick up a new

hobby like drawing, learning a new language, playing a musical instrument to help your brain form

strong connections and brain cells that can protect it in old age.


6. Build your social network for a nourished body and brain.


Have a strong social network of family and good friends can do wonders for your physical and

mental health. In fact, those who were lonely were twice more likely to develop diabetes than those

who had a good support system [23]. Being more social and meeting your friends regularly is

protective towards your brain as well. Older women who had a large social network where they met

their friends and family more than once a month, had a 26% lower risk of dementia [24]. Community

clubs, volunteers or joining a hobby group are some great ways to make new friends while mentally

stimulating your brain for added benefits, making it a win-win situation.



References


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